A research study  reveals protein that reverses aging of skeletal muscle


A University at Buffalo-led research team received partial grant funding by  the National Institute of Health (NIH) has shown that a protein is effective at reversing aging in skeletal muscle cells. Other grants were provided by the National Institute on Aging; a Veteran Affairs Biomedical Laboratory Research Development grant; and an Indian Trail Charitable Foundation grant.


The study was published Sept. 3 in Science Advances centering  on the protein NANOG. Interestingly, the term NANOG refers to mythical land of youth in Irish folklore. Researchers overexpressed NANOG in myoblasts, which are the embryonic precursors to muscle tissue. The myoblasts were senescent, translating  they were no longer able to divide and grow.



Cellular senescence due to aging or chronic disease impedes stem cell function and regeneration (1). Skeletal muscle is a highly regenerative organ that comprises ~45% of body mass and enables skeletal movements while also regulating metabolism. Muscle regeneration relies on myogenic progenitors that, when activated, proliferate, differentiate, and contribute to the regeneration of damaged myofibers. However, both the number of myogenic progenitors and their regenerative capacity decline with aging and cellular senescence (2).

Recently, we discovered that expression of NANOG in C2C12 myoblasts restored their myogenic differentiation potential, as evidenced by expression of myogenic regulatory factors and the ability to form myotubes, which was impaired by replicative senescence (27). This result prompted us to investigate the anti-aging effects of NANOG on primary human myoblasts and in skeletal muscle tissue in vivo. Here, we show that overexpression of NANOG reversed the hallmarks of cellular senescence in muscle progenitors in vitro and restored the satellite cell abundance in the skeletal muscle of LAKI progeria mice.

For more detailed information about this study , please reference: Science.org


Funding: NIH NHLBI R01 HL086582 (S.T.A.), NIA R01 AG052387 (S.T.A.), and NIA R01 AG068250 (S.T.A.); Veteran Affairs Biomedical Laboratory Research Development grant BX004369 (B.R.T.); NIH K07 AG060266 (B.R.T.); and Indian Trail Foundation grant (B.R.T.). Author contributions: Conceptualization: A.Sh. and S.T.A. Methodology: A.Sh., S.T.A, S.L., A.St., J.P., and P.L. Investigation: A.Sh., N.R., S.S., D.C., K.V., T.N., J.K., T.S., I.I., Y.Z., J.W., A.St., R.T., K.S., and J.P. Visualization: A.Sh. Supervision: S.T.A. Writing—original draft: A.Sh. and S.T.A. Writing—review and editing: A.Sh., S.T.A, P.L., B.R.T., and J.P.

Article Credits Science.org

Follow us on Google news for more updates and News


This content is being provided to you for informational purposes only. The content has been prepared by third parties not affiliated with CWEB Inc, a business. This content and any information contained therein, does not constitute a recommendation by CWEB to buy, sell or hold any security, financial product or instrument referenced in the content. This information neither is, nor should be construed as an offer, or a solicitation of an offer, to buy or sell securities by CWEB Inc. CWEB Inc. does not offer or provide any opinion regarding the nature, potential, value, suitability or profitability of any particular investment or investment strategy, and you shall be fully responsible for any investment decisions you make, and such decisions will be based solely on your evaluation of your financial circumstances, investment objectives, risk tolerance, and liquidity needs.

Unless stated otherwise, the web content provided by the CWEB family of companies is for educational purposes only. The information and tools provided neither are, nor should be construed, as an offer, or a solicitation of an offer, to buy or sell securities by CWEB Inc. or its affiliates. Unless stated otherwise, no information presented constitutes a recommendation by CWEB Inc. or its affiliates to buy, sell or hold any security, financial product or instrument discussed therein or to engage in any specific investment strategy.

Full Disclaimer