San Francisco wide receiver Deebo Samuel (shoulder) and running back Christian McCaffrey (oblique) were ruled out by the 49ers after exiting the 19-17 loss Sunday to the host Cleveland Browns.

McCaffrey, the NFL’s leading rusher entering Week 6, was deemed questionable to return in the fourth quarter before being ruled out.

Samuel played San Francisco’s first two series, but he was then taken to the medical tent before heading back to the locker room. The 49ers announced before the loss to the Browns that X-rays on Samuel’s shoulder were negative with an MRI exam scheduled.

Prior to exiting, Samuel was targeted once without a catch. He added a pair of carries for 11 yards.

He briefly returned to the game but jogged into the locker room with 1:23 on the clock in the third quarter.

McCaffrey caught a TD pass in the first half and had 11 carries for 43 yards with three receptions for 9 yards before exiting the game.

He entered Week 6 with an NFL-best 510 rushing yards.

Samuel, 27, entered Sunday with 20 receptions for 302 yards and a touchdown through five games this season. He also had 84 rushing yards and a score.

–Field Level Media